Entries by Mark McCarthy

Genome wide association analyses in type 2 diabetes: the gift that keeps on giving

By Mark McCarthy & Anubha Mahajan. Today, Nature Genetics published our manuscript describing the latest iteration of the series of genome wide association analysis for type 2 diabetes that we (as the DIAGRAM consortium) have completed over the past decade. For this round, we assembled genome-wide association data from nearly 900,000 individuals from 32 studies, […]

Birthweight And Diabetes: What Did We Find?

By Mark McCarthy & Rachel Freathy. With colleagues in the EGG (Early Growth Genetics) consortium, we recently published a paper in Nature describing genetic analyses of birth weight in over 150,000 samples. In this blog, we detail the rationale behind the study, summarise the main findings, and place the research in a wider context. The […]

In Praise Of UK Biobank

By Mark McCarthy & Rachel Freathy. Today, we published a paper in Nature in which we explore the genetic contribution to variation in birth weight. We describe how this information can help us to tease apart the contributions made by nature (i.e. inherited genetic variation) and nurture (i.e. the sum of environmental exposures) to the […]

The Value Of Collaborative Research

Our recent paper in Nature (Fuchsberger et al, published 11 July 2016) is a testament to the power of collaborative research. The samples that were examined came from individuals from 16 countries, with ancestral origins in Europe, Asia, Africa and the Americas. The author list includes over 300 scientists working in 22 countries. Funding to […]

Common vs rare, shared vs unique: a century of debate

One of the main questions we sought to address in the paper which we recently published in Nature [1] relates to the relative contribution of common (technically speaking, those with an allele frequency over 5%) as opposed to lower-frequency alleles with respect to  predisposition to type 2 diabetes (T2D). We concluded that the evidence is […]

Why did we do this research, and what did we find?

Type 2 diabetes is one of the major threats to global health. Around 10% of the world’s population either has type 2 diabetes, or is likely to develop it during their lives. Both genes and environment contribute to an individual’s risk of developing this disease. Preventative strategies currently available (for example, sustainable changes to diet […]