The McCarthy Group is a diabetes research group led by Prof Mark McCarthy (Robert Turner Professor of Diabetes), based at both the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) and the Wellcome Centre for Human Genetics (WHG). This multidisciplinary research team includes clinicians, research nurses, laboratory-based research staff and computational biologists. Read more about the group here

European DIAMANTE – Nature Genetics, 2018

Genome wide association analyses in type 2 diabetes: the gift that keeps on giving

By Mark McCarthy & Anubha Mahajan. Today, Nature Genetics published our manuscript describing the latest iteration of the series of genome wide association analysis for type 2 diabetes that we (as the DIAGRAM consortium) have completed…

ExTexT2D ExomeChip Smoking Gun – Nature Genetics, 2018

Of smoking guns, football and red herrings

In our recent paper (Mahajan et al, Nature Genetics 2018), we asked a simple question: how reliably does the finding that a common coding variant is associated with type 2 diabetes allow the “obvious” inference implicating that gene in disease…

Software & Tools

EGG Birthweight Paper – Nature, September 2016

A newborn being weighed.

Birthweight And Diabetes: What Did We Find?

By Mark McCarthy & Rachel Freathy. With colleagues in the EGG (Early Growth Genetics) consortium, we recently published a paper in Nature describing genetic analyses of birth weight in over 150,000 samples. In this blog, we detail the rationale…

In Praise Of UK Biobank

By Mark McCarthy & Rachel Freathy. Today, we published a paper in Nature in which we explore the genetic contribution to variation in birth weight. We describe how this information can help us to tease apart the contributions made by nature…
A newborn, undergoing phototherapy in a light box.

Birthweight And Later Life Disease: Unravelling Genetic Effects Of Child And Mother

By Rachel Freathy & Mark McCarthy. With colleagues in the EGG (Early Growth Genetics) Consortium, we have published a paper in Nature describing genetic analyses of birth weight. We have written about our main findings in a separate post.…

T2D Paper – Nature, July 2016

What have we learned about the genetics of Type 2 Diabetes?

Type 2 diabetes is a major global health threat ─ 1 in 10 people either has type 2 diabetes, or is likely to develop it during their life. But we are yet to fully understand what causes the disease and what puts people at risk – limiting…

The Value Of Collaborative Research

Our recent paper in Nature (Fuchsberger et al, published 11 July 2016) is a testament to the power of collaborative research. The samples that were examined came from individuals from 16 countries, with ancestral origins in Europe, Asia, Africa…

How can massive genetic studies help us prevent and treat diabetes?

An interview with Mark McCarthy, by Dr Emma O'Brian, Public Engagement and Communications Officer at the Radcliffe Department of Medicine. Professor McCarthy reflects about the insights revealed by this latest genetic research into Type 2…

Common vs rare, shared vs unique: a century of debate

One of the main questions we sought to address in the paper which we recently published in Nature [1] relates to the relative contribution of common (technically speaking, those with an allele frequency over 5%) as opposed to lower-frequency…

Why did we do this research, and what did we find?

Type 2 diabetes is one of the major threats to global health. Around 10% of the world’s population either has type 2 diabetes, or is likely to develop it during their lives. Both genes and environment contribute to an individual’s risk of…